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A delivery status message stating that the email could not be delivered to the address. A permanent fatal error message. Sometimes called a perm fail.
Common Reasons for getting a hard bounce
User does not exist for the given domain (eg there is no user named bob at example.com)
The domain does not exist (the domain nonexistantdomain.com doesn't exist)
What to do with Hard Bounces
Hard bounces should be removed from your mailing list, they are addresses that may have once worked but do not work anymore. Failure to remove hard bounces can have negative effects on your deliverability.